Check out the latest research from the last two weeks!

Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis.
Thanigaimani S, Singh T, Golledge J.
Topical oxygen therapy (TOT) has been suggested as a treatment for diabetes-related foot ulcer (DFU) but no prior meta-analyses of randomised clinical trials (RCT) have been reported. This systematic review and meta-analysis examined the randomised evidence for the benefit of TOT in healing DFU.

Demographics and outcomes of inpatients with diabetic foot ulcers treated conservatively and surgically in a metropolitan hospital network.
Rosi LM, Jones AS, Topliss DJ, Bach LA.
To describe the demographics of patients with diabetic foot ulcers (DFU) and their impact on inpatient management. Secondary outcomes identified relationships of treatment modality with mortality, length of hospital admission, readmissions and post-admission care.

Host DNA depletion efficiency of microbiome DNA enrichment methods in infected tissue samples.
Heravi FS, Zakrzewski M, Vickery K, Hu H.
In this study, we evaluated the host DNA depletion efficiency of four different microbiome DNA enrichment methods (NEBNext Microbiome DNA Enrichment kit, Molzym Ultra-Deep Microbiome Prep, QIAamp DNA Microbiome kit and Zymo HostZERO microbial DNA kit) in diabetic foot infection (DFI) tissue samples using quantitative real-time PCR and their effect on bacterial community composition by 16S ribosomal RNA amplicon sequencing.

Plantar soft tissues and Achilles tendon thickness and stiffness in people with diabetes: a systematic review.
Khor BYC, Woodburn J, Newcombe L, Barn R.
Diabetes mellitus is associated with changes in soft tissue structure and function. However, the directionality of this change and the extent to which either tissue thickness or stiffness contributes to the pathogenesis of diabetes-related foot ulcerations is unclear. Hence, this systematic review aims to summarise the existing evidence for soft tissue structural differences in the feet of people with and without diabetes.

Evaluation of clinical outcomes following minor amputations in Australia – an important consideration for timing of revascularisation.
Chiang N, Wang J, Marie N, Wu A, Ravindra R, Robinson D.
Vascular patients with tissue loss requiring minor amputations could be an early sign of a terminal event. The long-term outcomes and timing of revascularisation for these patients are not well-studied. The aim of this study was to determine the clinical outcomes following minor amputations. Primary outcomes were functional status, limb loss, and mortality. Secondary outcomes compared immediate and delayed revascularisation.

C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study.
Botheras CL, Bowe SJ, Cowan R, Athan E.
Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care.

Mobile Apps for Foot Measurement in Pedorthic Practice: Scoping Review.
Kabir MA, Rahman SS, Islam MM, Ahmed S, Laird C.
As the use of smartphones increases globally across various fields of research and technology, significant contributions to the sectors related to health, specifically foot health, can be observed. Numerous smartphone apps are now being used for providing accurate information about various foot-related properties. Corresponding to this abundance of foot scanning and measuring apps available in app stores, there is a need for evaluating these apps, as limited information regarding their evidence-based quality is available.