What’s new in Aussie research

It’s been a busy few months for DFD aussie research – so grab yourself a cuppa and check out the latest that has been released below!

Trends in the Incidence of Hospitalization for Major Diabetes-Related Complications in People With Type 1 and Type 2 Diabetes in Australia, 2010-2019.
This study included 70,885 people with type 1 and 1,089,270 people with type 2 diabetes registered on the Australian diabetes registry followed from July 2010 to June 2019.
Morton JI, Lazzarini PA, Shaw JE, Magliano DJ.
Diabetes Care. 2022 Jan 27:dc212268. doi: 10.2337/dc21-2268. Online ahead of print.

Factors influencing lower extremity amputation outcomes in people with active foot ulceration in regional Australia: A retrospective cohort study.
The aim of this study was to determine what factors contribute to the likelihood of LEA in people with active foot ulceration in regional Australia. This retrospective cohort study audited patients with active foot ulceration in a multidisciplinary high risk foot service (HRFS) in regional Australia. Neurological, vascular and wound characteristics were systematically extracted, along with demographic information.
Tehan PE, Hawes MB, Hurst J, Sebastian M, Peterson BJ, Chuter VH.
Wound Repair Regen. 2022 Jan;30(1):24-33. doi: 10.1111/wrr.12978. Epub 2021 Oct 26.
PMID: 34698428

The Effect of Structured Exercise Compared with Education on Neuropathic Signs and Symptoms in People at Risk of Neuropathic Diabetic Foot Ulcers: A Randomized Clinical Trial.
The aim of this study was to determine the effect of undertaking an exercise program in comparison with an education program on the signs and symptoms of peripheral neuropathy in people with diabetes at risk of neuropathic foot ulceration.
Perrin BM, Southon J, McCaig J, Skinner I, Skinner TC, Kingsley MIC.
Medicina (Kaunas). 2021 Dec 30;58(1):59. doi: 10.3390/medicina58010059.
PMID: 35056367 Free PMC article. Clinical Trial.

The evaluation of podiatrists, with knowledge and training in diagnostic musculoskeletal ultrasound, to describe sonographic images of diabetic foot wounds in the United Kingdom and Australia.
This scoping exercise explores the capacity of podiatrists with experience in interpreting musculoskeletal structures using USI to interpret sonographic images of DFU.
Dando C, Lane G, Bowen C, Henshaw F.
J Foot Ankle Res. 2022 Jan 25;15(1):5. doi: 10.1186/s13047-022-00511-0.
PMID: 35078511

Effectiveness of combined modulated ultrasound and electric current stimulation to treat diabetic foot ulcers.
This study aimed to investigate if combined ultrasound and electrostimulation is an effective adjunctive treatment for hard-to-heal DFUs when compared with standard wound care.
Hearne CLJ, Patton D, Moore ZE, Wilson P, Gillen C, O’Connor T.
J Wound Care. 2022 Jan 2;31(1):12-20. doi: 10.12968/jowc.2022.31.1.12.
PMID: 35077215 Clinical Trial.

Prevalence and risk factors of lower limb amputations in patients with diabetic foot ulcers: A systematic review and meta-analysis.
The study aimed at determining prevalence and risk factors (RFs) of diabetic lower limb amputations (LLAs).
Rodrigues BT, Vangaveti VN, Urkude R, Biros E, Malabu UH.
Diabetes Metab Syndr. 2022 Jan 14;16(2):102397. doi: 10.1016/j.dsx.2022.102397. Online ahead of print.
PMID: 35085918 Review.

Outcome trial data on sodium glucose cotransporter-2 inhibitors: Putting clinical benefits and risks in perspective.
Chiang B, Chew DP, De Pasquale CG.
Int J Cardiol. 2022 Feb 15;349:96-98. doi: 10.1016/j.ijcard.2021.12.015. Epub 2021 Dec 15.
PMID: 34920045 Clinical Trial.

The far side of the pandemic: Has diabetic foot osteomyelitis been neglected due to COVID-19?
Tsagkaris C, Laskaratou ED, Desse D, Kamaratos A.
Int J Health Plann Manage. 2022 Jan;37(1):572-574. doi: 10.1002/hpm.3369. Epub 2021 Oct 18.
PMID: 34664309 Free PMC article. No abstract available.

Initiation of SGLT2 Inhibitors and the Risk of Lower Extremity Minor and Major Amputation in Patients with Type 2 Diabetes and Peripheral Arterial Disease: A Health Claims Data Analysis.
To assess the association between long term risk of hospitalisation for heart failure (HHF) and lower extremity minor and major amputation (LEA) in patients initiating sodium glucose cotransporter 2 inhibitors (SGLT2i) suffering from type 2 diabetes and peripheral arterial disease (PAD).
Rodionov RN, Peters F, Marschall U, L’Hoest H, Jarzebska N, Behrendt CA.
Eur J Vasc Endovasc Surg. 2021 Dec;62(6):981-990. doi: 10.1016/j.ejvs.2021.09.031. Epub 2021 Nov 12.
PMID: 34782230

Hypertension and its related factors among patients with type 2 diabetes mellitus – a multi-hospital study in Bangladesh.
This study aimed to determine the prevalence, awareness and control of hypertension and factors associated with hypertension among people with type 2 diabetes mellitus (T2DM) in Bangladesh.
Alsaadon H, Afroz A, Karim A, Habib SH, Alramadan MJ, Billah B, Shetty AN.
BMC Public Health. 2022 Jan 29;22(1):198. doi: 10.1186/s12889-022-12509-1.

Extracellular matrix and cellular senescence in venous leg ulcers.
Lim DXE, Richards T, Kanapathy M, Sudhaharan T, Wright GD, Phillips ARJ, Becker DL.
Sci Rep. 2021 Oct 11;11(1):20168. doi: 10.1038/s41598-021-99643-9.
PMID: 34635751 Free PMC article.

Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD.
Castelblanco E, Sarrias MR, Betriu À, Soldevila B, Barranco-Altirriba M, Franch-Nadal J, Valdivielso JM, Bermudez-Lopez M, Groop PH, Fernández E, Alonso N, Mauricio D.
Aging (Albany NY). 2021 Oct 10;13(19):22690-22709. doi: 10.18632/aging.203615. Epub 2021 Oct 10.
PMID: 34629330 Free PMC article.

Evaluation of Clinical Outcomes Following Minor Amputations in Australia – An Important Consideration for Timing of Revascularisation.
The aim of this study was to determine the clinical outcomes following minor amputations. Primary outcomes were functional status, limb loss, and mortality. Secondary outcomes compared immediate and delayed revascularisation.
Chiang N, Wang J, Marie N, Wu A, Ravindra R, Robinson D.
Ann Vasc Surg. 2021 Oct;76:389-398. doi: 10.1016/j.avsg.2021.03.050. Epub 2021 Apr 24.
PMID: 33905853

Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, Flood V.
Br J Nutr. 2021 Nov 28;126(10):1451-1458. doi: 10.1017/S0007114520003815. Epub 2020 Sep 28.
PMID: 32981536 Clinical Trial.