A clinical screening score for diabetic polyneuropathy: KORA F4 and AusDiab studies

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Authors: Bongaerts,B. W.;Ziegler,D.;Shaw,J. E.;Heier,M.;Kowall,B.;Herder,C.;Roden,M.;Peters,A.;Meisinger,C.;Rathmann,W.

Publication: Journal of diabetes and its complications

Year: 2015

Volume: 29

Issue: 1

Start Page: 44


AIMS: Since screening for distal sensorimotor polyneuropathy (DSPN) in individuals with diabetes is being underused, our aim was to develop a clinical screening score for identifying individuals with DSPN.

METHODS: All participants with type 2 diabetes and aged 61-82 years from the German population-based KORA F4 Study (n=177) and the Australian population-based AusDiab Study (n=244) were combined into one study sample. Risk indicators of DSPN were identified and entered into a stepwise model-selection procedure, constructing two consecutive scores with increasing complexity (a base and clinical model).

RESULTS: The prevalence of DSPN was 18.2% (95% confidence interval (CI): 14.7-22.3). The base model comprised age (years), height (cm), weight (kg), pain or discomfort in the feet and/or legs (yes/no), and duration of diabetes (years), yielding an area under the receiver operating characteristics curve (AUC) of 0.80 (95% CI: 0.76-0.85). The clinical model additionally included diastolic blood pressure (mmHg) and serum creatinine levels (mmol/l). The AUC increased only marginally to 0.82 (0.77-0.87) (p for AUC comparison=0.188). The internal validation of the scores produced similar AUCs.

CONCLUSIONS: The screening scores developed in this study are a simple tool to differentiate between a high and low likelihood of having DSPN among individuals with type 2 diabetes.

  • Listing ID: 4632
  • Author/s: Bongaerts,B. W.;Ziegler,D.;Shaw,J. E.;Heier,M.;Kowall,B.;Herder,C.;Roden,M.;Peters,A.;Meisinger,C.;Rathmann,W.
  • Publication: Journal of diabetes and its complications
  • Year: 2015
  • Volume: 29
  • Issue: 1
  • Start Page: 44
  • Article Keywords: Age Distribution;Aged;Aged, 80 and over;Area Under Curve;Australia/epidemiology;Blood Glucose/analysis;Diabetes Mellitus, Type 2/diagnosis/epidemiology;Diabetic Neuropathies/diagnosis/epidemiology;Female;Germany/epidemiology;Humans;International Cooperation;Male;Mass Screening/organization & administration;Middle Aged;Prevalence;Reproducibility of Results;Severity of Illness Index;Sex Distribution;Australia;Diabetes mellitus;Distal sensorimotor polyneuropathy;Epidemiology;Germany;Screening score