Diabetes-related lower-extremity complications are a leading cause of the global burden of disability
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Authors: Lazzarini PA, Pacella RE, Armstrong DG, van Netten JJ
Publication: Diabetic Medicine
Globally ~435 million people have diabetes , and an estimated 19-34% (~83-148 million people) of those will be expected to develop foot ulcers in their lifetime . Foot ulcers are typically precipitated by other diabetes-related lower-extremity complications, (DRLECs) including peripheral neuropathy and peripheral vascular disease [2,3]. Collectively, DRLECs are a leading cause of infection, hospitalization and amputation outcomes [2-5], yet, these outcomes are readily preventable with evidence-based care [6,7]. This suggests the burden caused by DRLECs is a large, yet reducible, cause of the global burden of disease.